If you are losing weight, please keep this good news

Audit expert: Wu Xi

Deputy Chief Physician, Department of Endocrinology, Huashan Hospital, Fudan University, Doctor of Medicine

Obesity has become an increasingly common phenomenon in modern society. In recent years, the proportion of obese people in my country has been increasing, with more than 50% of adults and nearly 20% of children and adolescents being overweight and obese. The accelerated prevalence of obesity has become a serious public health problem.

Obesity source: pexels

In fact, obesity is a gastrointestinal regulation and metabolic disorder. Obesity is closely related to premature mortality, metabolic syndrome, cardiovascular system diseases and genetic diseases. 70% to 80% of diabetic patients have obesity before they become ill. Overweight and obesity also increase the risk of many other chronic diseases in adults. Therefore, a series of problems related to obesity have attracted the attention of many researchers, hoping to find safe, effective treatment targets with few side effects.

Recently, a new study discovered a new target for treating obesity, bringing new hope to fat people who have been unable to lose weight for a long time.

Good news is coming Source: Baidu Pictures

Recently, a study led by Professor Yin Zhinan from the Institute of Biomedical Translational Research at Jinan University revealed for the first time that interleukin-27 can act on obese mice, increasing the consumption of their fat cells and heat production, thereby improving obesity.

The research results of Professor Yin's team were published in Nature magazine Source: Nature

IL-27 can reduce obesity and improve type 2 diabetes IL-27 is a member of the interleukin cytokine family with anti-inflammatory and pro-inflammatory bidirectional regulatory effects and is involved in the immune regulation of many diseases.

Professor Yin Zhinan's team used transgenic technology to reduce the expression of the IL-27 gene in mice. After feeding them a high-fat diet, they found that these mice were highly sensitive to obesity induced by a high-fat diet and developed severe symptoms of diabetes and fatty liver. The study also showed that IL-27-deficient mice showed a variety of cell function changes, including thermogenesis in brown/beige fat cells. In simple terms, IL-27 can directly activate thermogenic proteins in fat cells, burning calories and consuming body fat.

Obese mice lose weight after injection of IL-27 Source: Nature

Seeing this, some people may ask, if IL-27 has the effect of inhibiting obesity, then for obese people, can IL-27 be supplemented to improve obesity and overweight?

In this regard, Professor Yin's team also conducted relevant research and found that IL-27 significantly reduced the body weight and fat content of obese mice, increased the body's sensitivity to insulin, and significantly improved insulin resistance and liver fatty degeneration.

This suggests that IL-27 can not only improve diabetes caused by insulin resistance, but may also be a new therapeutic target for obesity or other metabolic diseases.

So that's the source丨Sohu.com

Causes of obesity and related diseases - insulin abnormalities Insulin is the main regulator of energy storage and metabolism in the body. Its main function is to lower blood sugar levels and regulate blood sugar balance and body fat storage in a variety of ways. The normal function of insulin ensures that the body stores sufficient energy.

However, long-term excessive energy intake in obese individuals disrupts the balance between energy storage and consumption, leading to insulin resistance (IR) in target tissues such as adipose tissue, liver, and muscle.

Insulin resistance source丨Zhihu

IR refers to a pathological state in which the secretion level of insulin is normal or exceeds the normal level, but the human body does not respond to insulin, making it unable to regulate the body's blood sugar level and causing abnormalities. The main reason why IL-27 plays a role in weight loss and regulating fat metabolism is to improve insulin resistance (IR).

IR is an abnormality of endocrine homeostasis, which can increase the body's fat decomposition, blood sugar/blood lipid abnormalities, hormone secretion disorders, and cause oxidative stress and vascular damage. Therefore, IR is not only the main mechanism of diabetes, but also related to the induction of many diseases, including obesity, hypertension, atherosclerosis, polycystic ovary syndrome, non-alcoholic fatty liver, malignant tumors, chronic kidney disease, etc. Therefore, maintaining normal endocrine levels and curbing insulin resistance are essential for improving the body's obesity state.

Insulin resistance can lead to a variety of diseases Source: Sohu.com

Daily tips for losing weight

1. Eat a balanced diet and eat at regular times.

A reasonable diet can maintain the metabolic balance of body heat and prevent endocrine diseases. It is recommended that you have fixed meal times, reduce excessive fat intake, eat more low-energy foods (fruits, vegetables, etc.), and avoid consuming large amounts of high-energy foods (fried potato chips, chocolate, candy, etc.) and sugary carbonated drinks.

Eat more fruits and vegetables Source: pexels

2. Develop good living habits and keep a good mood.

Improve your lifestyle, learn to regulate your emotions, and maintain a good attitude. Depressed mental state and bad living habits will affect the body's endocrine system, leading to hormone disorders and causing disease over time.

Develop good living habits Source｜360 Pictures

3. Strengthen physical exercise to avoid the accumulation of body fat.

Long-term exercise can accelerate the consumption of body fat and improve one's own metabolic level. It is recommended to exercise at least 0.5-1 hour of moderate intensity every day; at the same time, reduce the time of resting life, such as watching TV, computer and mobile phone every day.

Keep exercising Source: pexels

The research results of Professor Yin's team have brought new hope for the treatment and intervention of obesity, and may be a target therapeutic drug for weight loss in the future. However, it will take a lot of effort to move this achievement from the laboratory to clinical application. In daily life, everyone should pay more attention to their bodies, maintain a good condition, and stay away from obesity.