Is there really no solution to getting pregnant with trisomy twice in a row?

I saw a netizen saying that she and her husband had done a checkup and there was no problem with their chromosomes, but in the previous two pregnancies, the fetuses were separated due to trisomy 13, and they thought they could not have a normal birth. As a result, while waiting in line for IVF, she got pregnant naturally again, and this time she successfully gave birth to a healthy baby, who is now over 2 years old. The doctor also said that after giving birth to a healthy baby, the chance of abnormality will be much lower next time, but she got pregnant again not long after, and the fetus stopped growing at nine weeks, and the test showed chromosomal abnormalities again. If she wanted to have a child, she could only do the third generation, and she didn't dare to try again.

She was also confused. What was the problem? As a biological person, when seeing such a problem, I have to say a few words.

01 About this disease

I consulted the literature and found that the main causes of this disease are as follows:

1. When germ cells are generated (balanced translocation)

So this is the basis for my first suggestion to you. It is very likely that there is a problem between you two. Since your egg was formed after you were born, and your husband's sperm was produced later, I suggest that you test your egg and your husband test his sperm or peripheral blood.

2. When the fertilized egg divides

If it is not the above reasons, both of you are normal. But when the egg cell begins the meiosis process after fertilization (your egg has not actually undergone meiosis or is at most in the early stage when fertilization occurs), ectopic occurs, which may have something to do with your body. This may be the main reason for your problem , which is the source of my suggestion 2.

3. Age at conception is the biggest risk factor

This is a document I found about chromosomal abnormalities, which also mentions this disease. The incidence rate increases significantly after the age of 28.

So, if you really want to find out, you still have to do some investigation.

02 Do you have any good suggestions?

What good suggestions do you have for the above problems?

1. Test your eggs and your husband’s genome

Note that it must be your egg, not peripheral blood (the egg is fixed and has nothing to do with your genome).

Your husband can just have his peripheral blood tested (because sperm is constantly being resynthesized).

Since the hospital can detect trisomy, just give the sample to them.

2. Artificial insemination and then testing the fertilized egg (this is the beginning, just don't treat it as a life). At this time, cross-experimentation (other people's eggs and sperm) can be done.

The reason for doing the second one is that if 1 is excluded, then only 2 can be considered.

Finally, normal chromosomes are one of the important factors in giving birth to a healthy baby, but they cannot completely guarantee the birth of a healthy baby.