007 almost fell in front of the "lie detector plasma"! What exactly is "lie detector plasma"?

007, the memory of a generation. At that time, everyone was impressed by his wisdom, courage and superpowers.

In reality, we all hope to be 007 and be omnipotent. However, even such a "god man" almost fell in front of a kind of "lie detector plasma".

The so-called "lie detector plasma" is a drug used by the enemy to deal with spies. After the suspect takes the drug, his mind is no longer under his control. If it is an ordinary person, he will almost "say whatever you ask."

Apparently, 007 was "abnormal". As a British spy who had infiltrated the German army, he had to ensure that his identity was not exposed at all times. During one of the tests on him by the enemy, he stubbornly resisted the effects of the drug - he answered the questions without any flaws.

In fact, the reason why 007 is "omnipotent" is that he had taken precautions. As the German army tightened its internal review, he asked a doctor to gradually give him medication to improve his tolerance to the drugs.

After setting a time, their test began:

At first, the doctor gave him a small dose of 25 mg, which, according to doctors at the time, was enough to semi-paralyze his nervous system.

Soon, 007 felt dizzy, nauseous, and sleepy. Everything in front of him seemed very interesting and strange, and everyone was so cute. When he felt his tongue swelled to the point where his mouth couldn't hold it anymore, he called out to the doctor beside him: Come on, start asking questions.

However, despite the doctor's attempts to trick him into revealing some secrets with various questions, he was able to restrain himself, which showed that this person was indeed not an ordinary person.

25 mg was not enough, so he asked the doctor to increase the dose to 50 mg. This time, 007 either avoided, denied, or lied. He kept the secret until the drug took effect and he fell asleep.

Although he was strong-willed, he was still a mortal after all. The 50 mg of sodium thiopental made him sleep until the next day.

At this point, everyone must be curious about what drugs he used?

It's a drug called sodium thiopental, which was used by psychiatrists to treat soldiers' post-traumatic stress disorder during World War II and was subsequently tested by multiple spy agencies.

Anesthesiologists of a certain age are familiar with this drug. It was officially launched in 1935 and was still used as a first-line anesthetic until the 1990s. Every year, this drug saves tens of thousands of lives.

According to the instructions, the common dosage of sodium thiopental is 4 to 8 mg per kilogram of body weight for intravenous injection in adults. In other words, a 60-kilogram person needs to be injected with 240 mg to 480 mg to achieve the effect of clinical anesthesia.

Seeing that 007 was also numb by 50 mg, some friends would say disdainfully: That won’t work!

In fact, from a professional perspective, 50 mg is indeed a large dose. If you are not in good physical condition, you may even suffer from severe respiratory depression and lose your life. It can be seen that this 007 was really dedicated. The reason why today's anesthesiologists can easily use such "toxic" drugs to anesthetize patients is that anesthesiologists have many safety measures to ensure that patients "fall asleep safely and wake up safely."

At this point someone may ask: Were all the drugs used in previous interrogations sodium thiopental?

This is not necessarily the case. Different drugs played important roles in different periods. To this end, we need to take a look at the history of "lie detector plasma".

In fact, the past and present life of "lie detector plasma" was called "truth serum".

When you see this name, you will know what it does. Yes, it makes you tell the truth.

Around the 1910s, an obstetrician and gynecologist named House noticed that the popular obstetric anesthetic scopolamine put patients into a state of semi-dream and semi-wakefulness, where they not only babble spontaneously but also answer questions posed by House. Dr. House subsequently published this discovery, and the term "truth serum" was officially born.

Thiopental is a barbiturate drug that acts on GABA neurons, prolongs the opening time of chloride channels, and inhibits neuronal excitability. Thiopental can quickly suppress the anxiety caused by fear and worry, making people feel relaxed and talkative. Increasing the dose can cause people to lose consciousness or even enter an anesthesia state.

Because of this shameful experience, sodium thiopental has both good and bad reputations. But compared with another notorious and highly toxic hallucinogen, lysergic acid diethylamide, sodium thiopental can make people completely ignore its dark history.

Lysergic acid diethylamide was first synthesized in 1938. During the "hippie movement" of the 1960s, the legal and cheap lysergic acid diethylamide quickly became popular among hippies, leaving a strong fantasy footnote for contemporary youth culture.

Existing studies have found that lysergic acid diethylamide can bind to almost all monoamine G protein-coupled receptors. 5-hydroxytryptamine receptors are the main central nervous system lysergic acid diethylamide receptors, in addition to dopamine receptors and glutamate receptors. Therefore, lysergic acid diethylamide can widely attack various areas of the cortex and induce body perception, synesthesia, thought disorders and time and space distortion.

It's scary to think about it, this is a drug that can almost completely make people lose control. Therefore, it is normal that it is banned.

Of course, the "banned" here refers to life and "non-medical use". In fact, in the medical field, scientists are trying to explore its application in patients with severe mental illness. Once this drug is on the market, it and similar psychiatric drugs will definitely attract the attention of anesthesiologists.

Someone asked: What is the relationship between psychiatric drugs and your anesthesiology department?

This is because monoamine oxidase inhibitors increase the concentration of 5 HT in the brain and accumulate the convulsant metabolite of pethidine (norpethidine); the combined use of monoamine oxidase inhibitors and pethidine will produce central nervous system excitement symptoms such as agitation, convulsions, high fever and convulsions; monoamine oxidase inhibitors and morphine have similar interactions and generally cannot be used together.

If you still don’t understand, think about the sodium thiopental mentioned above, which is a real anesthetic.

In fact, from the perspective of anesthesia, all drugs that can cause mental changes can be used as "truth serums." The same is true for alcohol in life.

Alcohol has many targets in the central nervous system, such as GABA receptors, NMDA receptors, G protein-regulated potassium channels, large-conductance potassium channels, small-conductance calcium-activated potassium channels, etc. Due to individual differences in ethanol metabolism and receptor binding, there is no recommended dose that can maintain memory and basic cognitive levels under sedation.

So, friends who drink, be careful! Be careful not to tell your secrets!

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