A new "door" to functional materials! Femtosecond laser printing of artificial micro-vessels

Author: Duan Yuechu

Li Jiawen, an associate professor at the University of Science and Technology of China, and his research group proposed a femtosecond laser dynamic holographic processing method suitable for the efficient construction of three-dimensional capillary scaffolds, which can be used to generate three-dimensional capillary networks. The related research was recently published as a cover article in Advanced Functional Materials, and the related technology was patented.

Femtosecond laser dynamic holographic processing is a technology that uses ultrashort pulse lasers for micro-nano processing. Its characteristics are that it can achieve fine processing of materials and micro-nano structural control. This technology has unique advantages in manufacturing microstructures because it can achieve high-precision cutting of materials and micro-nano surface modification. Especially when constructing three-dimensional microstructures, femtosecond laser dynamic holographic processing can achieve fine processing and rapid production of complex structures, providing important technical support for the construction of microvascular networks.

The construction of a three-dimensional capillary network is of great significance for tissue engineering. In the preparation of artificial tissues and organs, a good blood supply system is an important guarantee for cell survival and function. However, traditional in vitro tissue engineering preparation often fails to effectively construct a vascular system that is compatible with it, resulting in a lack of effective blood supply to cells after implantation in vivo. Therefore, the construction of a three-dimensional capillary network with physiological functions is crucial to achieve the long-term stable growth of artificial tissues and to exert their functions. The introduction of femtosecond laser dynamic holographic processing methods provides new possibilities and technical support for the construction of microvascular networks. Through this method, the efficient construction of microvascular scaffolds can be achieved, providing a new solution for in vitro tissue engineering.

Femtosecond laser dynamic holographic processing methods have unique advantages for the efficient construction of three-dimensional capillary scaffolds. First, the femtosecond laser dynamic holographic processing method can achieve high-precision processing and structural control at the microscale, and its processing accuracy can reach the submicron or even nanometer level. This provides an important technical basis for the construction of microscopic vascular scaffolds and can achieve more delicate and complex structures. Secondly, the femtosecond laser dynamic holographic processing method has the characteristics of fast processing speed and high molding efficiency. It can complete the preparation of complex microstructures in a shorter time, which makes it possible to prepare three-dimensional capillary networks on a large scale. Therefore, the application of femtosecond laser dynamic holographic processing methods has important technical advantages in the construction of three-dimensional capillary scaffolds.

The relevant research results have been published in Advanced Functional Materials, which marks an important breakthrough in the field of three-dimensional capillary network construction using femtosecond laser dynamic holographic processing methods. The publication of this result not only proves the feasibility and innovation of this technology in the construction of microvascular networks, but also lays the foundation for subsequent research and application in this field. Through the publication of academic journals, the relevant research results will receive wider recognition and attention, which will help promote the application and promotion of this technology in the field of tissue engineering.

In addition, the relevant technology has also obtained patent authorization, which means that the research has made important progress in technological innovation and intellectual property protection. Patent authorization is not only an important honor for the scientific research team, but more importantly, it can provide strong support for subsequent industrial applications and commercial transformation. The protection of intellectual property rights can ensure the legal status of relevant technologies in market competition, which is conducive to attracting more funds and resources to invest in the research and development and industrialization of relevant technologies, and promote the better transformation of scientific research results into productivity.

The application prospects of artificial microvascular networks are very broad. First of all, this technology is of great significance in the field of tissue engineering and regenerative medicine. It can provide important physiological support for the construction of artificial organs and tissues, help solve the problem of vascular blood supply faced in traditional tissue engineering, and provide the necessary conditions for the long-term stable function of artificial organs. Secondly, the construction of artificial microvascular networks also provides new research tools and platforms for fields such as drug screening and disease model establishment, which helps to promote the research and application process in related fields. In the future, with the continuous improvement and promotion of artificial microvascular network technology, it is believed that it will show great application potential in many fields such as medicine and bioengineering, and bring new hope and opportunities to human health.

From the above introduction, it is not difficult to see that the femtosecond laser dynamic holographic processing method has important significance and broad application prospects in the field of artificial microvascular network construction. With the continuous advancement and improvement of related technologies, it is believed that it will bring major changes and breakthroughs in the fields of tissue engineering and regenerative medicine, and make important contributions to human health. In the future development path, we expect this technology to be more widely used and bring more surprises and hopes to human life and health.

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