"Fan Hua" made pork ribs and rice cakes popular. Although they are delicious, what should you do if you eat too much? Do you know?

Question:

In the hit drama "Flowering",

What you prefer

Is it the mysterious, beautiful, charming and elusive Li Li on the Yellow River Road?

Or is it Lingzi , the virtuous, shrewd, tough-mouthed, soft-hearted, worldly-wise, and coquettish woman in Night Tokyo?

Or is it Miss Wang in Room 27 of the Foreign Trade Building, who is outspoken, clear-headed and bright, and who doesn’t fight for money or reputation?

Of course I chose...

Pork ribs rice cake .

No matter how good things are outside,

After all, it can't be compared with pork ribs and rice cakes~

Fragrant pork ribs rice cake,

Satisfied the people

Pursuit of a happy life

Good wishes~

Recently, a TV series "Fang Hua" has made a Shanghai snack popular, or a snack in the free shipping area of ​​Jiangsu, Zhejiang and Shanghai - pork ribs and rice cakes . Pork ribs and rice cakes have the freshness of pork ribs and the softness and crispness of rice cakes, attracting countless people to check in.

However, although pork ribs and rice cakes are delicious, eating too much can easily lead to indigestion.

How is your stomach?

At this time, people often think of a popular advertising slogan: "Bloating and indigestion? Ask Domperidone for help." So, is it really appropriate to use Domperidone (also known as Domperidone) for bloating and indigestion ?

Domperidone can be used to treat indigestion, but only after professional evaluation

The generic name of metoclopramide is domperidone, which is a peripheral dopamine receptor antagonist. Among the indications approved by the State Food and Drug Administration, domperidone can be used for dyspepsia caused by delayed gastric emptying, gastroesophageal reflux, and esophagitis. The specific manifestations are:

Upper abdominal fullness and bloating

Upper abdominal pain

Belching and flatulence

Nausea and vomiting

Stomach burning sensation

In addition, domperidone can also be used for nausea and vomiting caused by functional, organic, infectious, dietary, radiotherapy or chemotherapy, and dopamine receptor agonists (such as levodopa, bromocriptine, etc.) can be used to treat nausea and vomiting caused by Parkinson's disease.

Although the drug instructions clearly state that domperidone is suitable for the treatment of indigestion, it needs to be evaluated by a professional doctor or pharmacist before it can be used . The specific reasons can be explained from several warnings of domperidone~

01

In 2012, Health Canada released a report on the risk of arrhythmia and sudden cardiac death associated with domperidone.

02

In 2014, the European Medicines Agency issued a warning and recommendation: its indications are limited to nausea and vomiting, and it is no longer used to treat bloating and heartburn.

03

In 2016, the China Food and Drug Administration decided to revise the [Adverse Reactions], [Contraindications], [Precautions], [Usage and Dosage] and other items in the instructions for use of over-the-counter and prescription drugs of domperidone preparations.

04

In 2022, the China National Drug Administration once again revised the [Adverse Reactions] and [Precautions] of the domperidone instructions, clarifying that the drug should be used with caution in children under 12 years old (especially infants), adolescents weighing less than 35 kg, and adults, and adverse reactions should be closely monitored during use.

Through these warnings and the revision of the instructions in China, it is not difficult to find that there are certain risks during the use of domperidone, and unauthorized use of the drug may cause irreparable harm to the patient himself. In addition, it is worth noting that the US FDA has not approved domperidone for marketing in the United States.

So, how to take domperidone correctly?

After evaluating patients who really need to take domperidone due to indigestion, we recommend that their dosage should follow the principle of " short time, small dose ":

01

Adults (weight ≥ 35 kg)

Take 10 mg three times a day. Generally, do not exceed 30 mg per day.

02

Children (age ≥12 years and weight ≥35 kg)

Take orally up to 3 times a day, 10 mg each time.

Domperidone should be used at the lowest effective dose, with the shortest possible duration of administration, and the longest duration of treatment should not usually exceed 1 week. The medication should be taken 15 to 30 minutes before meals.

Domperidone cannot

Use with these drugs

Do not use with drugs that prolong the QT interval

Such as: clarithromycin, amiodarone. Co-administration may increase the relevant risks.

Do not use with strong CYP3A4 enzyme inhibitors

Such as: fluconazole, voriconazole, ritonavir; combined use will lead to an increase in the blood concentration of domperidone in the body.

It should not be taken at the same time as antacids or drugs that inhibit gastric acid secretion

Taking them at the same time will reduce the oral bioavailability of domperidone. Domperidone should be taken before meals, and antacids or drugs that inhibit gastric acid secretion should be taken after meals.

It should not be used with drugs that may cause electrolyte imbalance

Coadministration may increase the patient's likelihood of developing torsades de pointes.

In addition to domperidone,

What other prokinetic drugs are there?

According to the mechanism of action, commonly used prokinetic drugs can be divided into three categories :

01

Dopamine receptor antagonists, commonly used representative drugs include metoclopramide and domperidone;

02

5-HT receptor agonists, commonly used representative drugs include mosapride, etc.

03

Opioid receptor agonists, the commonly used representative drug is trimebutine maleate;

The differences between these three types of drugs can be seen in the table below:

Doctors remind pharmacists to remind everyone that one should not eat too much delicious food as overeating can easily harm the body and one should be moderate in diet in daily life.

If you do experience symptoms of indigestion, it is recommended that you go to the hospital for relevant examinations to rule out organic diseases, and then receive drug treatment after professional evaluation .